The research group formed by Assistant Professor Masaki Igarashi, Dr. Yoshiko Nakagawa, Dr. Masaomi Miura, and Professor Toshimasa Yamauchi of the Department of Diabetes and Metabolism, University of Tokyo Hospital, administered orally NMN, a precursor of NAD+, in a randomized, placebo-controlled, double-blind experiment to healthy male seniors to study its effects on the aging phenomenon, starting with muscular weakness.
The healthy elderly men took 250 mg of NMN per day for 12 weeks. As a result, their levels of NAD+ and related metabolites in blood increased and motor functions, such as walking or holding objects, improved. Furthermore, it was found that the oral intake of NMN tends to improve hearing.
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